Unknown

Dataset Information

0

Myocardial injury after noncardiac surgery-incidence and predictors from a prospective observational cohort study at an Indian tertiary care centre.


ABSTRACT: Asymptomatic myocardial injury following noncardiac surgery (MINS) is an independent predictor of 30-day mortality and may go unrecognized based on standard diagnostic definition for myocardial infarction (MI). Given lack of published research on MINS in India, our study aims to determine incidence of MINS in patients undergoing noncardiac surgery at our tertiary care hospital, and evaluate the clinical characteristics including 30-day outcome.The prospective observational study included patients >65 years or >45 years with either hypertension (HTN), diabetes mellitus (DM), coronary artery disease (CAD), cerebrovascular accident (CVA), or peripheral arterial disease undergoing noncardiac surgery. MINS was peak troponin level of ?0.03 ng/dL at 12-hour or 24-hour postoperative. All patients were followed for 30 days postoperatively. Predictors of MINS and mortality were analyzed using multivariate logistic regression. Patients categorized based on peak troponin cut-off values determined by receiver operating characteristic curve were analyzed by Kaplan-Meir test to compare the survival of patients between the groups.Among 1075 patients screened during 34-month period, the incidence of MINS was 17.5% (188/1075). Patients with DM, CAD, or who underwent peripheral nerve block anaesthesia were 1.5 (P?1 ng/mL (P?=?.01) were significantly associated with mortality. A peak troponin cut-off of >0.152 ng/mL predicted mortality among MINS patients at 72% sensitivity and 58% specificity. Lack of antithrombotic therapy following MINS was independent predictor of mortality (P?

SUBMITTER: George R 

PROVIDER: S-EPMC5959425 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Myocardial injury after noncardiac surgery-incidence and predictors from a prospective observational cohort study at an Indian tertiary care centre.

George Rubin R   Menon Vidya P VP   Edathadathil Fabia F   Balachandran Sabarish S   Moni Merlin M   Sathyapalan Dipu D   Prasanna Preetha P   S Gokuldas G   Paul Jerry J   K K Chandrababu C   Kumar Lakshmi L   Pillai Ashok A  

Medicine 20180501 19


Asymptomatic myocardial injury following noncardiac surgery (MINS) is an independent predictor of 30-day mortality and may go unrecognized based on standard diagnostic definition for myocardial infarction (MI). Given lack of published research on MINS in India, our study aims to determine incidence of MINS in patients undergoing noncardiac surgery at our tertiary care hospital, and evaluate the clinical characteristics including 30-day outcome.The prospective observational study included patient  ...[more]

Similar Datasets

| S-EPMC7678162 | biostudies-literature
| S-EPMC6703687 | biostudies-literature
| S-EPMC6676775 | biostudies-literature
| S-EPMC8261888 | biostudies-literature
| S-EPMC10953137 | biostudies-literature
| S-EPMC10446234 | biostudies-literature
| S-EPMC7083480 | biostudies-literature
| S-EPMC8465750 | biostudies-literature
| S-EPMC8348325 | biostudies-literature
| S-EPMC10335561 | biostudies-literature