Dataset Information

Efficiency and adverse events of electronic cigarettes: A systematic review and meta-analysis (PRISMA-compliant article).

ABSTRACT:

Background

Electronic cigarettes (e-cigarettes) are a prevalent smoking cessation aid worldwide; however, a consensus regarding their efficacy and safety has yet to be reached.

Methods

We conducted a systematic review of the literature from related studies written in English or Chinese and published between January 1, 2003, and July 30, 2017. Eligible studies reporting the number of smokers who reduced or quit smoking and suffered from adverse events after e-cigarette use were selected according to predefined criteria; pertinent data were then extracted for a meta-analysis.

Results

Our search produced 198 articles; of these publications, 14 including 35,665 participants were analyzed. The pooled efficacy rate of e-cigarettes ranged from 48.3% to 58.7% for smoking reduction and from 13.2% to 22.9% for smoking cessation. The pooled rate of adverse events associated with e-cigarettes ranged from 49.1% to 51.6% based on 11 studies including 16,406 participants. The most prevalent adverse events were mouth or throat irritation, anxiety, depressed mood, nausea, and insomnia. No significant differences in overall CO2 exhalation (eCO) levels were observed after e-cigarette use according to the data from 5 studies.

Conclusion

Our findings suggest that e-cigarettes are moderately effective with regard to smoking reduction and smoking cessation. eCO levels are unreliable for evaluating the efficacy of e-cigarettes. E-cigarette related adverse events frequently occur, especially due to high-dose nicotine-containing cartridges.

SUBMITTER: Liu X

PROVIDER: S-EPMC5959444 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Publications

Efficiency and adverse events of electronic cigarettes: A systematic review and meta-analysis (PRISMA-compliant article).

Liu Xing X Lu Wan W Liao Sheng S Deng Zhongliang Z Zhang Zhongrong Z Liu Yun Y Lu Weizhong W

Medicine 20180501 19

<h4>Background</h4>Electronic cigarettes (e-cigarettes) are a prevalent smoking cessation aid worldwide; however, a consensus regarding their efficacy and safety has yet to be reached.<h4>Methods</h4>We conducted a systematic review of the literature from related studies written in English or Chinese and published between January 1, 2003, and July 30, 2017. Eligible studies reporting the number of smokers who reduced or quit smoking and suffered from adverse events after e-cigarette use were sel ...[more]

PMID: 29742683

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Dataset Information

Efficiency and adverse events of electronic cigarettes: A systematic review and meta-analysis (PRISMA-compliant article).

Background

Methods

Results

Conclusion

Publications

Efficiency and adverse events of electronic cigarettes: A systematic review and meta-analysis (PRISMA-compliant article).

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