Ontology highlight
ABSTRACT:
SUBMITTER: Irani S
PROVIDER: S-EPMC5959753 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Irani Seema S Naowarojna Nathchar N Tang Yang Y Kathuria Karan R KR Wang Shu S Dhembi Anxhela A Lee Norman N Yan Wupeng W Lyu Huijue H Costello Catherine E CE Liu Pinghua P Zhang Yan Jessie YJ
Cell chemical biology 20180301 5
Sulfur incorporation in the biosynthesis of ergothioneine, a histidine thiol derivative, differs from other well-characterized transsulfurations. A combination of a mononuclear non-heme iron enzyme-catalyzed oxidative C-S bond formation and a subsequent pyridoxal 5'-phosphate (PLP)-mediated C-S lyase reaction leads to the net transfer of a sulfur atom from a cysteine to a histidine. In this study, we structurally and mechanistically characterized a PLP-dependent C-S lyase Egt2, which mediates th ...[more]