Ontology highlight
ABSTRACT:
SUBMITTER: Iriondo O
PROVIDER: S-EPMC5959931 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Iriondo Oihana O Liu Yarong Y Lee Grace G Elhodaky Mostafa M Jimenez Christian C Li Lin L Lang Julie J Wang Pin P Yu Min M
Nature communications 20180518 1
Triple-negative breast cancer (TNBC) is a highly metastatic subtype of breast cancer that has limited therapeutic options. Thus, developing novel treatments for metastatic TNBC is an urgent need. Here, we show that nanoparticle-mediated delivery of transforming growth factor-β1-activated kinase-1 (TAK1) inhibitor 5Z-7-Oxozeaenol can inhibit TNBC lung metastasis in most animals tested. P38 is a central signal downstream of TAK1 in TNBC cells in TAK1-mediated response to multiple cytokines. Follow ...[more]