Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez LW
PROVIDER: S-EPMC5960067 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20171025 44
A concise synthesis of (+)-pancratistatin and (+)-7-deoxypancratistatin from benzene using an enantioselective, dearomative carboamination strategy has been achieved. This approach, in combination with the judicious choice of subsequent olefin-type difunctionalization reactions, permits rapid and controlled access to a hexasubstituted core. Finally, minimal use of intermediary steps as well as direct, late stage C-7 hydroxylation provides both natural products in six and seven operations. ...[more]