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Bordetella pertussis in children hospitalized with a respiratory infection: clinical characteristics and pathogen detection in household contacts.

ABSTRACT: OBJECTIVE:Describe the prevalence of Bordetella pertussis via PCR in children under 5 years old hospitalized as probable cases of pertussis and report the most common clinical features among them. RESULTS:A positive PCR result for B. pertussis was observed in 20.5% of our samples (18/88), one-third of them were from infants between 2 and 3 months old. The most common symptoms were paroxysms of coughing (88.9%), difficulty breathing (72.2%), cyanosis (77.8%) and fever (50%). The mother was the most common symptomatic carrier (27.8%), followed by uncles/aunts (22.2%) among children with pertussis.

SUBMITTER: Del Valle-Mendoza J

PROVIDER: S-EPMC5960213 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Bordetella pertussis in children hospitalized with a respiratory infection: clinical characteristics and pathogen detection in household contacts.

Del Valle-Mendoza Juana J Silva-Caso Wilmer W Aguilar-Luis Miguel Angel MA Del Valle-Vargas Cristina C Cieza-Mora Erico E Martins-Luna Johanna J Aquino-Ortega Ronald R Silva-Vásquez Andrea A Bazán-Mayra Jorge J Weilg Pablo P

BMC research notes 20180518 1

<h4>Objective</h4>Describe the prevalence of Bordetella pertussis via PCR in children under 5 years old hospitalized as probable cases of pertussis and report the most common clinical features among them.<h4>Results</h4>A positive PCR result for B. pertussis was observed in 20.5% of our samples (18/88), one-third of them were from infants between 2 and 3 months old. The most common symptoms were paroxysms of coughing (88.9%), difficulty breathing (72.2%), cyanosis (77.8%) and fever (50%). The mo ...[more]

PMID: 29776433

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Risk factors for Bordetella pertussis disease in hospitalized children.

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[Detection and analysis of bocavirus in hospitalized children with respiratory infection].

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Bordetella pertussis Strain Lacking Pertactin and Pertussis Toxin.

Project description:A Bordetella pertussis strain lacking 2 acellular vaccine immunogens, pertussis toxin and pertactin, was isolated from an unvaccinated infant in New York State in 2013. Comparison with a French strain that was pertussis toxin-deficient, pertactin wild-type showed that the strains carry the same 28-kb deletion in similar genomes.

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