Ontology highlight
ABSTRACT:
SUBMITTER: Xu XX
PROVIDER: S-EPMC5960442 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Xu Xing-Xing XX Luo Jian-Hong JH
Neuroscience bulletin 20171110 3
Epilepsy is one of the most common neurological diseases. Of all cases, 70%-80% are considered to be due to genetic factors. In recent years, a large number of genes have been identified as being involved in epilepsy. Among them, N-methyl-D-aspartate receptor (NMDAR) subunit-encoding genes represent a large proportion, suggesting an important role for NMDARs in epilepsy. In this review, we summarize and analyze the genotypes, functional alterations, and clinical aspects of NMDAR subunit mutation ...[more]