Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis.
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ABSTRACT:
SUBMITTER: Gaschler MM
PROVIDER: S-EPMC5960802 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis.
Gaschler Michael M MM Hu Fanghao F Feng Huizhong H Linkermann Andreas A Min Wei W Stockwell Brent R BR
ACS chemical biology 20180313 4
Ferroptosis is a form of nonapoptotic cell death characterized by the unchecked accumulation of lipid peroxides. Ferrostatin-1 and its analogs (ferrostatins) specifically prevent ferroptosis in multiple contexts, but many aspects of their molecular mechanism of action remain poorly described. Here, we employed stimulated Raman scattering (SRS) microscopy coupled with small vibrational tags to image the distribution of ferrostatins in cells and found that they accumulate in lysosomes, mitochondri ...[more]
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