Ontology highlight
ABSTRACT:
SUBMITTER: Knijnenburg TA
PROVIDER: S-EPMC5961503 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Knijnenburg Theo A TA Wang Linghua L Zimmermann Michael T MT Chambwe Nyasha N Gao Galen F GF Cherniack Andrew D AD Fan Huihui H Shen Hui H Way Gregory P GP Greene Casey S CS Liu Yuexin Y Akbani Rehan R Feng Bin B Donehower Lawrence A LA Miller Chase C Shen Yang Y Karimi Mostafa M Chen Haoran H Kim Pora P Jia Peilin P Shinbrot Eve E Zhang Shaojun S Liu Jianfang J Hu Hai H Bailey Matthew H MH Yau Christina C Wolf Denise D Zhao Zhongming Z Weinstein John N JN Li Lei L Ding Li L Mills Gordon B GB Laird Peter W PW Wheeler David A DA Shmulevich Ilya I Monnat Raymond J RJ Xiao Yonghong Y Wang Chen C
Cell reports 20180401 1
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying loss of heterozygosity were observed in over 1/3 of DDR genes, including TP53 and BRCA1/2. Other prevalent alterations included epigenetic silencing of the direct repair genes EXO5, MGMT, and ALKBH3 in ∼20% of samples. Homologous recombination deficiency (H ...[more]