Helicobacter pylori genetic diversification in the Mongolian gerbil model.

ABSTRACT: Helicobacter pylori requires genetic agility to infect new hosts and establish long-term colonization of changing gastric environments. In this study, we analyzed H. pylori genetic adaptation in the Mongolian gerbil model. This model is of particular interest because H. pylori-infected gerbils develop a high level of gastric inflammation and often develop gastric adenocarcinoma or gastric ulceration. We analyzed the whole genome sequences of H. pylori strains cultured from experimentally infected gerbils, in comparison to the genome sequence of the input strain. The mean annualized single nucleotide polymorphism (SNP) rate per site was 1.5e^-5, which is similar to the rates detected previously in H. pylori-infected humans. Many of the mutations

SUBMITTER: Beckett AC 

PROVIDER: S-EPMC5961626 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature