Ontology highlight
ABSTRACT:
SUBMITTER: Woodard JL
PROVIDER: S-EPMC5962029 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Woodard John L JL Huntsman Andrew C AC Patel Pratiq A PA Chai Hee-Byung HB Kanagasabai Ragu R Karmahapatra Soumendrakrishna S Young Alexandria N AN Ren Yulin Y Cole Malcolm S MS Herrera Denisse D Yalowich Jack C JC Kinghorn A Douglas AD Burdette Joanna E JE Fuchs James R JR
Bioorganic & medicinal chemistry 20180323 9
A series of arylnaphthalene lignan lactones based on the structure of the phyllanthusmins, a class of potent natural products possessing diphyllin as the aglycone, has been synthesized and screened for activity against multiple cancer cell lines. SAR exploration was performed on both the carbohydrate and lactone moieties of this structural class. These studies have revealed the importance of functionalization of the carbohydrate hydroxy groups with both acetylated and methylated analogues showin ...[more]