Ontology highlight
ABSTRACT:
SUBMITTER: Ye J
PROVIDER: S-EPMC5962418 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Ye Jiayu J Farrington Caitlin R CR Millard Julie T JT
Mutation research 20180320
DNA oligonucleotides containing site-specific N7-guanine monoadducts of cisplatin, diepoxybutane, and epichlorohydrin were used as templates for DNA synthesis by two bacterial DNA polymerases and human polymerase β. These polymerases were able to bypass the lesions effectively, although the efficiency was decreased, with inhibition increasing with the size of the lesion. Fidelity of incorporation was essentially unaltered, suggesting that N7-guanine monoadducts do not significantly contribute to ...[more]