Ontology highlight
ABSTRACT:
SUBMITTER: Yuan X
PROVIDER: S-EPMC5962552 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Yuan Xiefang X Wang Junyi J Li Yin Y He Xiang X Niu Bin B Wu Dehong D Lan Nan N Wang Xiaoyun X Zhang Yun Y Dai Xi X Wang Xing X Liu Zhigang Z Li Guoping G
Scientific reports 20180521 1
Constant exposure to allergen triggers destructive type 2 cell-mediated inflammation. The effect of allergen specific immunotherapy (SIT) in maintaining airway epithelial barrier function in asthma remains unknown. In the current study, we showed that SIT maintained airway epithelial homeostasis in mice exposed to dermatophagoides farinae (Der f), which induced increased expression of IL-25, endoplasmic reticulum (ER) stress and airway epithelial apoptosis. Meanwhile, SIT treatment ameliorated a ...[more]