Ontology highlight
ABSTRACT:
SUBMITTER: Goncalves IDCG
PROVIDER: S-EPMC5962575 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Gonçalves Inês do Carmo G IDCG Brecht Johanna J Thelen Maximilian P MP Rehorst Wiebke A WA Peters Miriam M Lee Hyun Ju HJ Motameny Susanne S Torres-Benito Laura L Ebrahimi-Fakhari Darius D Kononenko Natalia L NL Altmüller Janine J Vilchez David D Sahin Mustafa M Wirth Brunhilde B Kye Min Jeong MJ
Scientific reports 20180521 1
Dysregulated miRNA expression and mutation of genes involved in miRNA biogenesis have been reported in motor neuron diseases including spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). Therefore, identifying molecular mechanisms governing miRNA expression is important to understand these diseases. Here, we report that expression of DROSHA, which is a critical enzyme in the microprocessor complex and essential for miRNA biogenesis, is reduced in motor neurons from an SMA mous ...[more]