Ontology highlight
ABSTRACT:
SUBMITTER: Qin H
PROVIDER: S-EPMC5962598 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Qin Hecong H Carroll Valerie N VN Sriram Renuka R Villanueva-Meyer Javier E JE von Morze Cornelius C Wang Zhen Jane ZJ Mutch Christopher A CA Keshari Kayvan R KR Flavell Robert R RR Kurhanewicz John J Wilson David M DM
Scientific reports 20180521 1
Oxidative stress is a critical feature of several common neurologic disorders. The brain is well adapted to neutralize oxidative injury by maintaining a high steady-state concentration of small-molecule intracellular antioxidants including glutathione in astrocytes and ascorbic acid in neurons. Ascorbate-derived imaging probes for hyperpolarized <sup>13</sup>C magnetic resonance spectroscopy and positron emission tomography have been used to study redox changes (antioxidant depletion and reactiv ...[more]