Ontology highlight
ABSTRACT:
SUBMITTER: Ding J
PROVIDER: S-EPMC5962608 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Ding Jiarui J Condon Anne A Shah Sohrab P SP
Nature communications 20180521 1
Single-cell RNA-sequencing has great potential to discover cell types, identify cell states, trace development lineages, and reconstruct the spatial organization of cells. However, dimension reduction to interpret structure in single-cell sequencing data remains a challenge. Existing algorithms are either not able to uncover the clustering structures in the data or lose global information such as groups of clusters that are close to each other. We present a robust statistical model, scvis, to ca ...[more]