Combination Therapy Strategies Against Multiple-Resistant <i>Streptococcus Suis</i>.

ABSTRACT: Streptococcus suis is a major swine pathogen, an emerging zoonotic agent responsible for meningitis, endocarditis and septicaemia followed by deafness in humans. The development of antimicrobial resistance in S. suis increases the risk for therapeutic failure in both animals and humans. In this study, we report the synergism of combination therapy against multi-resistant S. suis isolates from swine. Twelve antibiotic profiles were determined against 11 S. suis strains. To investigate their synergistic/antagonistic activity, checkerboard assay was performed for all the possible combinations. In-vitro killing curves and in-vivo treatment trials were used to confirm the synergistic activity of special combinations against S. suis dominant clone

SUBMITTER: Yu Y 

PROVIDER: S-EPMC5962770 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature