Dataset Information

Variations in the PBEF1 gene are associated with body mass index: A population-based study in northern China.

ABSTRACT: Objective:PBEF1 and its polymorphisms may be important in the physiopathology of obesity. We hypothesized that polymorphisms in PBEF1 gene may modify body mass index (BMI). Methods:Thus, we systematically screened 4 tagging polymorphisms (rs4730153, rs2058540, rs3801267 and rs16872158) in PBEF1 gene and evaluated the association between the genetic variants and BMI in a population-based study including 442 subjects in northern China. Results:We found that the SNP rs3801267 was significantly associated with decreased BMI (P = 0.026 in additive model), while the other 2 SNPs (rs4730153 and rs16872158) showed a borderline significant association with decreased BMI (P = 0.068 and 0.060 in additive models). Combined analysis of these 3 SNPs showed a significant allele-dosage association between the number of variant alleles and decreased BMI (P trend = 0.007). Conclusions:These findings indicate that genetic variants in PBEF1 gene may modify individual BMI in the Chinese population.

SUBMITTER: Rong J

PROVIDER: S-EPMC5963396 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Variations in the <i>PBEF1</i> gene are associated with body mass index: A population-based study in northern China.

Rong Jiesheng J Chu Minjie M Xing Baifen B Zhu Lin L Wang Shengyu S Tao Tianzun T Zhao Yashuang Y Jiang Liying L

Meta gene 20150921

<h4>Objective</h4><i>PBEF1</i> and its polymorphisms may be important in the physiopathology of obesity. We hypothesized that polymorphisms in <i>PBEF1</i> gene may modify body mass index (BMI).<h4>Methods</h4>Thus, we systematically screened 4 tagging polymorphisms (rs4730153, rs2058540, rs3801267 and rs16872158) in <i>PBEF1</i> gene and evaluated the association between the genetic variants and BMI in a population-based study including 442 subjects in northern China.<h4>Results</h4>We found th ...[more]

PMID: 30941280

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Project description:BackgroundLeptin is a peptide hormone secreted by adipose tissue and is an important determinant of obesity and its complications. The purpose of this study was to establish sex- and body mass index (BMI)-specific reference intervals for serum leptin in a Chinese population and investigate the factors influencing leptin concentrations.MethodsFasting serum leptin levels were assayed in 469 men and 773 women from randomly sampled Chinese residents. Blood glucose, insulin, hemoglobin A1c (HbA1c), liver enzymes, blood lipid profiles, creatinine, and uric acid (UA) levels were measured. Pearson's correlation coefficient and multiple linear regression analyses were used to estimate the relationship between serum leptin level and other variables. The reference intervals were determined by the 2.5th and 97.5th percentiles.ResultsThe mean ± standard deviation serum leptin level was much higher in women (20.92 ± 12.96 ng/mL) than in men (6.45 ± 5.53 ng/mL). The reference interval of serum leptin was 0.33-19.85 ng/mL in men and 3.60-54.86 ng/mL in women. The specific reference intervals of serum leptin in men with BMI of 20 to < 25 and 25 to < 27.5 kg/m2 were 0.42-12.32 and 2.17-20.22 ng/ml, respectively. The specific reference intervals of serum leptin in women with BMI of 20 to < 25 and 25 to < 27.5 kg/m2 were 4.11-38.09 and 8.27-48.66 ng/ml, respectively. BMI was significantly correlated with Ln (leptin) both in men (r = 0.698, P < 0.001) and women (r = 0.626, P < 0.001). In multivariate linear regression analysis, serum leptin was correlated with BMI, homeostasis model assessment of insulin resistance (HOMA-IR), UA in women, and plus triglyceride (TG) in men. The variance in serum leptin levels could be partially explained by these variables in both women (adjusted R2 = 0.447) and men (adjusted R2 = 0.552). In participants with leptin levels higher than the reference intervals, significantly higher levels of HOMA-IR, low-density lipoprotein cholesterol (LDL-C), UA, a higher proportion of central obesity (waist circumference [WC] > 90 cm), and metabolic syndrome were found in men, and significantly higher levels of HOMA-IR, UA and a higher proportion of central obesity (WC > 85 cm) were found in women.ConclusionThis is the first study to establish sex- and BMI-specific reference intervals of leptin for both sexes in a large Chinese population. Serum concentration of leptin was predicted by BMI, HOMA-IR, UA in women, and TG in men.

Dataset Information

Variations in the PBEF1 gene are associated with body mass index: A population-based study in northern China.

Publications

Variations in the <i>PBEF1</i> gene are associated with body mass index: A population-based study in northern China.

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