Ontology highlight
ABSTRACT:
SUBMITTER: Sailer A
PROVIDER: S-EPMC5963695 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Sailer Anne A Anneken Alexander A Li Younan Y Lee Sam S Munro Edwin E
Developmental cell 20151001 1
Dynamic maintenance of cell polarity is essential for development and physiology. Here we combine experiments and modeling to elucidate mechanisms that maintain cortical polarity in the C. elegans zygote. We show that polarity is dynamically stabilized by two coupled cross-inhibitory feedback loops: one involves the oligomeric scaffold PAR-3 and the kinase PAR-1, and the other involves CDC-42 and its putative GAP CHIN-1. PAR-3 and CDC-42 are both required locally to recruit PAR-6/PKC-3, which in ...[more]