Unknown

Dataset Information

0

Suzuki-Miyaura Coupling of Simple Ketones via Activation of Unstrained Carbon-Carbon Bonds.


ABSTRACT: Here, we describe that simple ketones can be efficiently employed as electrophiles in Suzuki-Miyaura coupling reactions via catalytic activation of unstrained C-C bonds. A range of common ketones, such as cyclopentanones, acetophenones, acetone and 1-indanones, could be directly coupled with various arylboronates in high site-selectivity, which offers a distinct entry to more functionalized aromatic ketones. Preliminary mechanistic study suggests that the ketone ?-C-C bond was cleaved via oxidative addition.

SUBMITTER: Xia Y 

PROVIDER: S-EPMC5963696 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Suzuki-Miyaura Coupling of Simple Ketones via Activation of Unstrained Carbon-Carbon Bonds.

Xia Ying Y   Wang Jianchun J   Dong Guangbin G  

Journal of the American Chemical Society 20180417 16


Here, we describe that simple ketones can be efficiently employed as electrophiles in Suzuki-Miyaura coupling reactions via catalytic activation of unstrained C-C bonds. A range of common ketones, such as cyclopentanones, acetophenones, acetone and 1-indanones, could be directly coupled with various arylboronates in high site-selectivity, which offers a distinct entry to more functionalized aromatic ketones. Preliminary mechanistic study suggests that the ketone α-C-C bond was cleaved via oxidat  ...[more]

Similar Datasets

| S-EPMC6977462 | biostudies-literature
| S-EPMC2593899 | biostudies-literature
| S-EPMC6059653 | biostudies-literature
| S-EPMC4080724 | biostudies-literature
| S-EPMC6017724 | biostudies-literature
| S-EPMC4131606 | biostudies-literature
| S-EPMC5424447 | biostudies-literature
| S-EPMC7456303 | biostudies-literature
| S-EPMC5906067 | biostudies-literature
| S-EPMC5474734 | biostudies-literature