Ontology highlight
ABSTRACT:
SUBMITTER: Grote CW
PROVIDER: S-EPMC5963702 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Grote Caleb W CW Wilson Natalie M NM Katz Natalie K NK Guilford Brianne L BL Ryals Janelle M JM Novikova Lesya L Stehno-Bittel Lisa L Wright Douglas E DE
Experimental neurology 20180409
Insulin is known to have neurotrophic properties and loss of insulin support to sensory neurons may contribute to peripheral diabetic neuropathy (PDN). Here, genetically-modified mice were generated in which peripheral sensory neurons lacked the insulin receptor (SNIRKO mice) to determine whether disrupted sensory neuron insulin signaling plays a crucial role in the development of PDN and whether SNIRKO mice develop symptoms of PDN due to reduced insulin neurotrophic support. Our results reveale ...[more]