Ontology highlight
ABSTRACT:
SUBMITTER: Thompson LW
PROVIDER: S-EPMC5963842 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Thompson Luke W LW Morrison Kim D KD Shirran Sally L SL Groen Ewout J N EJN Gillingwater Thomas H TH Botting Catherine H CH Sleeman Judith E JE
Journal of cell science 20180417 8
Spinal muscular atrophy (SMA) is an inherited neurodegenerative condition caused by a reduction in the amount of functional survival motor neuron (SMN) protein. SMN has been implicated in transport of mRNA in neural cells for local translation. We previously identified microtubule-dependent mobile vesicles rich in SMN and SNRPB, a member of the Sm family of small nuclear ribonucleoprotein (snRNP)-associated proteins, in neural cells. By comparing the interactomes of SNRPB and SNRPN, a neural-spe ...[more]