A bibliometric review of drug repurposing.
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ABSTRACT:
SUBMITTER: Baker NC
PROVIDER: S-EPMC5963941 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
A bibliometric review of drug repurposing.
Baker Nancy C NC Ekins Sean S Williams Antony J AJ Tropsha Alexander A
Drug discovery today 20180109 3
We have conducted a bibliometric review of drug repurposing by scanning >25 million papers in PubMed and using text-mining methods to gather, count and analyze chemical-disease therapeutic relationships. We find that >60% of the ∼35,000 drugs or drug candidates identified in our study have been tried in more than one disease, including 189 drugs that have been tried in >300 diseases each. Whereas in the majority of cases these drugs were applied in therapeutic areas close to their original use, ...[more]
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