Ontology highlight
ABSTRACT:
SUBMITTER: Prow NA
PROVIDER: S-EPMC5964325 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Prow Natalie A NA Liu Liang L Nakayama Eri E Cooper Tamara H TH Yan Kexin K Eldi Preethi P Hazlewood Jessamine E JE Tang Bing B Le Thuy T TT Setoh Yin Xiang YX Khromykh Alexander A AA Hobson-Peters Jody J Diener Kerrilyn R KR Howley Paul M PM Hayball John D JD Suhrbier Andreas A
Nature communications 20180326 1
Zika and chikungunya viruses have caused major epidemics and are transmitted by Aedes aegypti and/or Aedes albopictus mosquitoes. The "Sementis Copenhagen Vector" (SCV) system is a recently developed vaccinia-based, multiplication-defective, vaccine vector technology that allows manufacture in modified CHO cells. Herein we describe a single-vector construct SCV vaccine that encodes the structural polyprotein cassettes of both Zika and chikungunya viruses from different loci. A single vaccination ...[more]