Dataset Information

Clinicoradiologic features distinguish tumefactive multiple sclerosis from CNS neoplasms.

ABSTRACT:

Background

There are limited data to guide clinicians in differentiating tumefactive multiple sclerosis (TMS) from CNS neoplasms. Identifying distinguishing features will inform diagnosis and management and avoid unnecessary diagnostic biopsy. Our study aimed to determine the clinical and radiologic features that differentiate TMS from glioma and CNS lymphoma (CNSL) in patients who present with tumefactive lesions.

Methods

We retrospectively reviewed all patients with tumefactive lesions and histologically proven or clinically diagnosed TMS, glioma, or CNSL at our tertiary center from 1999 to 2012. Two independent blinded neuroradiologists rated MRI brain scans at presentation. We correlated patients' demographic, clinical, laboratory, and radiologic data to final diagnosis.

Results

A total of 133 patients (10 TMS, 85 glioma, 38 CNSL) were analyzed. Patients with TMS were younger and a greater proportion were women. Presenting symptoms did not distinguish between diagnoses. TMS lesions were smaller compared to glioma and CNSL, had no or mild mass effect, and were always associated with contrast enhancement. Radiologic features that were more frequent in TMS lesions were incomplete rim (open-ring) enhancement, incomplete peripheral diffusion restriction, and mixed T2 signal and CT hypoattenuation of MRI-enhancing components (all p < 0.05).

Conclusions

Radiologic features but not presenting symptoms are useful in distinguishing TMS from CNS neoplasms.

SUBMITTER: Lin X

PROVIDER: S-EPMC5964866 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Publications

Clinicoradiologic features distinguish tumefactive multiple sclerosis from CNS neoplasms.

Lin Xuling X Yu Wai-Yung WY Liauw Lishya L Chander Russell Jude RJ Soon Weiling E WE Lee Hwei Yee HY Tan Kevin K

Neurology. Clinical practice 20170201 1

<h4>Background</h4>There are limited data to guide clinicians in differentiating tumefactive multiple sclerosis (TMS) from CNS neoplasms. Identifying distinguishing features will inform diagnosis and management and avoid unnecessary diagnostic biopsy. Our study aimed to determine the clinical and radiologic features that differentiate TMS from glioma and CNS lymphoma (CNSL) in patients who present with tumefactive lesions.<h4>Methods</h4>We retrospectively reviewed all patients with tumefactive ...[more]

PMID: 29849229

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Dataset Information

Clinicoradiologic features distinguish tumefactive multiple sclerosis from CNS neoplasms.

Background

Methods

Results

Conclusions

Publications

Clinicoradiologic features distinguish tumefactive multiple sclerosis from CNS neoplasms.

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