A population-based study of the risk of osteoporosis and fracture with dutasteride and finasteride.

ABSTRACT: BACKGROUND:Dutasteride is a potent inhibitor of 5-alpha reductase enzymes that reduces concentrations of dihydrotestosterone to a greater extent than finasteride. Whether this has adverse implications for bone health is unknown. We compared the risk of osteoporosis and fractures in older men treated with dutasteride or finasteride. METHODS:We conducted a population-based retrospective cohort study with high-dimensional propensity score matching of Ontario men aged 66 years or older who started treatment with dutasteride or finasteride between January 1, 2006 and December 31, 2012. The primary outcome was a diagnosis of osteoporosis within 2 years of treatment initiation. A secondary outcome was osteoporotic or fragility fractures. RESULTS:We studied 31,615 men treated with dutasteride and

SUBMITTER: Antoniou T 

PROVIDER: S-EPMC5964967 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature