Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma.
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ABSTRACT:
SUBMITTER: Cancer Genome Atlas Research Network. Electronic address: andrew_aguirre@dfci.harvard.edu
PROVIDER: S-EPMC5964983 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma.
Cancer cell 20170801 2
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS, BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbore ...[more]
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