Ontology highlight
ABSTRACT:
SUBMITTER: Dale J
PROVIDER: S-EPMC5965697 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Dale Jahrane J Zhou Haocheng H Zhang Qiaosheng Q Martinez Erik E Hu Sile S Liu Kevin K Urien Louise L Chen Zhe Z Wang Jing J
Cell reports 20180501 5
Acute pain evokes protective neural and behavioral responses. Chronic pain, however, disrupts normal nociceptive processing. The prefrontal cortex (PFC) is known to exert top-down regulation of sensory inputs; unfortunately, how individual PFC neurons respond to an acute pain signal is not well characterized. We found that neurons in the prelimbic region of the PFC increased firing rates of the neurons after noxious stimulations in free-moving rats. Chronic pain, however, suppressed both basal s ...[more]