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Scaling Up Cortical Control Inhibits Pain.

ABSTRACT: Acute pain evokes protective neural and behavioral responses. Chronic pain, however, disrupts normal nociceptive processing. The prefrontal cortex (PFC) is known to exert top-down regulation of sensory inputs; unfortunately, how individual PFC neurons respond to an acute pain signal is not well characterized. We found that neurons in the prelimbic region of the PFC increased firing rates of the neurons after noxious stimulations in free-moving rats. Chronic pain, however, suppressed both basal spontaneous and pain-evoked firing rates. Furthermore, we identified a linear correlation between basal and evoked firing rates of PFC neurons, whereby a decrease in basal firing leads to a nearly 2-fold reduction in pain-evoked response in chronic pain states. In contrast, enhancing basal PFC activity with low-frequency optogenetic stimulation scaled up prefrontal outputs to inhibit pain. These results demonstrate a cortical gain control system for nociceptive regulation and establish scaling up prefrontal outputs as an effective neuromodulation strategy to inhibit pain.

SUBMITTER: Dale J

PROVIDER: S-EPMC5965697 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Scaling Up Cortical Control Inhibits Pain.

Dale Jahrane J Zhou Haocheng H Zhang Qiaosheng Q Martinez Erik E Hu Sile S Liu Kevin K Urien Louise L Chen Zhe Z Wang Jing J

Cell reports 20180501 5

Acute pain evokes protective neural and behavioral responses. Chronic pain, however, disrupts normal nociceptive processing. The prefrontal cortex (PFC) is known to exert top-down regulation of sensory inputs; unfortunately, how individual PFC neurons respond to an acute pain signal is not well characterized. We found that neurons in the prelimbic region of the PFC increased firing rates of the neurons after noxious stimulations in free-moving rats. Chronic pain, however, suppressed both basal s ...[more]

PMID: 29719246

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Scaling Up Cortical Control Inhibits Pain.

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Scaling Up Cortical Control Inhibits Pain.

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