A blueprint for human whole-cell modeling.
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ABSTRACT:
SUBMITTER: Szigeti B
PROVIDER: S-EPMC5966287 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
A blueprint for human whole-cell modeling.
Szigeti Balázs B Roth Yosef D YD Sekar John A P JAP Goldberg Arthur P AP Pochiraju Saahith C SC Karr Jonathan R JR
Current opinion in systems biology 20171109
Whole-cell dynamical models of human cells are a central goal of systems biology. Such models could help researchers understand cell biology and help physicians treat disease. Despite significant challenges, we believe that human whole-cell models are rapidly becoming feasible. To develop a plan for achieving human whole-cell models, we analyzed the existing models of individual cellular pathways, surveyed the biomodeling community, and reflected on our experience developing whole-cell models of ...[more]
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