Ontology highlight
ABSTRACT:
SUBMITTER: Sugg KB
PROVIDER: S-EPMC5966786 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Sugg Kristoffer B KB Markworth James F JF Disser Nathaniel P NP Rizzi Andrew M AM Talarek Jeffrey R JR Sarver Dylan C DC Brooks Susan V SV Mendias Christopher L CL
American journal of physiology. Cell physiology 20171213 4
Platelet-derived growth factor receptor (PDGFR) signaling plays an important role in the fundamental biological activities of many cells that compose musculoskeletal tissues. However, little is known about the role of PDGFR signaling during tendon growth and remodeling in adult animals. Using the hindlimb synergist ablation model of tendon growth, our objectives were to determine the role of PDGFR signaling in the adaptation of tendons subjected to a mechanical growth stimulus, as well as to inv ...[more]