Ontology highlight
ABSTRACT:
SUBMITTER: Zou LS
PROVIDER: S-EPMC5966887 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
BMC genomics 20180523 1
<h4>Background</h4>Bisulfite sequencing is widely employed to study the role of DNA methylation in disease; however, the data suffer from biases due to coverage depth variability. Imputation of methylation values at low-coverage sites may mitigate these biases while also identifying important genomic features associated with predictive power.<h4>Results</h4>Here we describe BoostMe, a method for imputing low-quality DNA methylation estimates within whole-genome bisulfite sequencing (WGBS) data. ...[more]