Ontology highlight
ABSTRACT:
SUBMITTER: Chamaa F
PROVIDER: S-EPMC5967150 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Chamaa Farah F Bahmad Hisham F HF Makkawi Ahmad-Kareem AK Chalhoub Reda M RM Al-Chaer Elie D ED Bikhazi George B GB Nahas Ziad Z Abou-Kheir Wassim W
Frontiers in cellular neuroscience 20180517
The identification of distinct and more efficacious antidepressant treatments is highly needed. Nitrous oxide (N<sub>2</sub>O) is an N-methyl-D-aspartic acid (NMDA) antagonist that has been reported to exhibit antidepressant effects in treatment-resistant depression (TRD) patients. Yet, no studies have investigated the effects of sub-anesthetic dosages of N<sub>2</sub>O on hippocampal cell proliferation and neurogenesis in adult brain rats. In our study, adult male Sprague-Dawley rats were expos ...[more]