An inhibitory pull-push circuit in frontal cortex.
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ABSTRACT:
SUBMITTER: Garcia-Junco-Clemente P
PROVIDER: S-EPMC5967235 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
An inhibitory pull-push circuit in frontal cortex.
Garcia-Junco-Clemente Pablo P Ikrar Taruna T Tring Elaine E Xu Xiangmin X Ringach Dario L DL Trachtenberg Joshua T JT
Nature neuroscience 20170123 3
Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull-push influence on excitatory neurons-an inversion of the canonical push-pull ...[more]
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