Ontology highlight
ABSTRACT:
SUBMITTER: Gomez JL
PROVIDER: S-EPMC5967238 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Gomez Jose L JL Yan Xiting X Holm Carole T CT Grant Nicole N Liu Qing Q Cohn Lauren L Nezgovorova Vera V Meyers Deborah A DA Bleecker Eugene R ER Crisafi Gina M GM Jarjour Nizar N NN Rogers Linda L Reibman Joan J Chupp Geoffrey L GL
The European respiratory journal 20171012 4
The chitinase-like protein YKL-40 mediates airway inflammation and serum levels are associated with asthma severity. However, asthma phenotypes associated with YKL-40 levels have not been precisely defined.We conducted an unsupervised cluster analysis of asthma patients treated at the Yale Center for Asthma and Airways Disease (n=156) to identify subgroups according to YKL-40 level. The resulting YKL-40 clusters were cross-validated in cohorts from the Severe Asthma Research Programme (n=167) an ...[more]