Ontology highlight
ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC5967248 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Wu Yanming Y Zhang Zhao Z Cenciarini Mauro E ME Proietti Cecilia J CJ Amasino Matias M Hong Tao T Yang Mei M Liao Yiji Y Chiang Huai-Chin HC Kaklamani Virginia G VG Jeselsohn Rinath R Vadlamudi Ratna K RK Huang Tim Hui-Ming TH Li Rong R De Angelis Carmine C Fu Xiaoyong X Elizalde Patricia V PV Schiff Rachel R Brown Myles M Xu Kexin K
Cancer research 20171206 3
Resistance to cancer treatment can be driven by epigenetic reprogramming of specific transcriptomes in favor of the refractory phenotypes. Here we discover that tamoxifen resistance in breast cancer is driven by a regulatory axis consisting of a master transcription factor, its cofactor, and an epigenetic regulator. The oncogenic histone methyltransferase EZH2 conferred tamoxifen resistance by silencing the expression of the estrogen receptor α (ERα) cofactor GREB1. In clinical specimens, induct ...[more]