Ontology highlight
ABSTRACT:
SUBMITTER: Xu S
PROVIDER: S-EPMC5967320 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Xu Shuting S Zhu Xinyuan X Zhang Chuan C Huang Wei W Zhou Yongfeng Y Yan Deyue D
Nature communications 20180524 1
Cancer cells in hypoxic tumors are remarkably resistant to photodynamic therapy. Here, we hypothesize that an oxygen and Pt(II) self-generating multifunctional nanocomposite could reverse the hypoxia-triggered PDT resistance. The nanocomposite contains Pt(IV) and chlorin e6, in which upconversion nanoparticles are loaded to convert 980 nm near-infrared light into 365 nm and 660 nm emissions. Upon accumulation at the tumor site, a 980 nm laser is used to trigger the nanocomposite to generate O<su ...[more]