Restoring anti-oncodriver Th1 responses with dendritic cell vaccines in HER2/neu-positive breast cancer: progress and potential.
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ABSTRACT:
SUBMITTER: De La Cruz LM
PROVIDER: S-EPMC5967360 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Restoring anti-oncodriver Th1 responses with dendritic cell vaccines in HER2/neu-positive breast cancer: progress and potential.
De La Cruz Lucy M LM Nocera Nadia F NF Czerniecki Brian J BJ
Immunotherapy 20161001 10
HER2/neu is expressed in the majority of in situ breast cancers, but maintained in 20-30% of invasive breast cancer (IBC). During breast tumorigenesis, there is a progressive loss of anti-HER2 CD4(pos) Th1 (anti-HER2Th1) from benign to ductal carcinoma in situ, with almost complete loss in IBC. This anti-HER2Th1 response can predict response to neoadjuvant therapy, risk of recurrence and disease-free survival. Vaccines consisting of HER2-pulsed type I polarized dendritic cells (DC1) administered ...[more]
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