Ontology highlight
ABSTRACT:
Results: VO2peak relative to body weight (ml/kgBW/min), fat-free mass (FFM) and by percent of predicted VO2peak obtained were not significantly different between children, adolescents and young adults. VO2peak did not longitudinally change over a mean time of ~5 years in late adolescent and young adult participants with repeated tests. A model including both cardiac and skeletal muscle variables best predicted VO2peak.
Conclusions: In conclusion, VO2peak relative to body weight and fat-free mass demonstrates short- and long-term stability from childhood to young adulthood in BTHS with some variability among individuals.
SUBMITTER: Cade WT
PROVIDER: S-EPMC5967725 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Cade William Todd WT Bohnert Kathryn L KL Reeds Dominic N DN Peterson Linda R LR Bittel Adam J AJ Bashir Adil A Byrne Barry J BJ Taylor Carolyn L CL
PloS one 20180524 5
Barth syndrome (BTHS) is an ultra-rare, X-linked recessive disorder characterized by cardio-skeletal myopathy, exercise intolerance, and growth delay. Oxygen uptake during peak exercise (VO2peak) has been shown to be severely limited in individuals with BTHS however; the trajectory of VO2peak from childhood to young adulthood is unknown. The objective of this study was to describe VO2peak from childhood through young adulthood in BTHS.<h4>Methods and materials</h4>VO2peak over time was presented ...[more]