Structure-based analysis of CysZ-mediated cellular uptake of sulfate.
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ABSTRACT:
SUBMITTER: Assur Sanghai Z
PROVIDER: S-EPMC5967866 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Structure-based analysis of CysZ-mediated cellular uptake of sulfate.
Assur Sanghai Zahra Z Liu Qun Q Clarke Oliver B OB Belcher-Dufrisne Meagan M Wiriyasermkul Pattama P Giese M Hunter MH Leal-Pinto Edgar E Kloss Brian B Tabuso Shantelle S Love James J Punta Marco M Banerjee Surajit S Rajashankar Kanagalaghatta R KR Rost Burkhard B Logothetis Diomedes D Quick Matthias M Hendrickson Wayne A WA Mancia Filippo F
eLife 20180524
Sulfur, most abundantly found in the environment as sulfate (SO<sub>4</sub><sup>2-</sup>), is an essential element in metabolites required by all living cells, including amino acids, co-factors and vitamins. However, current understanding of the cellular delivery of SO<sub>4</sub><sup>2-</sup> at the molecular level is limited. CysZ has been described as a SO<sub>4</sub><sup>2-</sup> permease, but its sequence family is without known structural precedent. Based on crystallographic structure info ...[more]
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