Ontology highlight
ABSTRACT:
SUBMITTER: Kalra R
PROVIDER: S-EPMC5968032 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Kalra Rashi R Bhagyaraj Ella E Tiwari Drishti D Nanduri Ravikanth R Chacko Anuja P AP Jain Monika M Mahajan Sahil S Khatri Neeraj N Gupta Pawan P
Oncogenesis 20180525 5
Early stage prostate cancers are dependent on androgens for their growth and survival and androgen withdrawal causes them to regress. Progressive prostate cancers eventually acquire androgen independence rendering anti-androgen therapy ineffective. However, the factors leading to this have not been adequately addressed. This study shows that AIRE finds differential expression in androgen-dependent and -independent prostate cancer cells. AIRE expression is more in androgen-independent cells due t ...[more]