Ontology highlight
ABSTRACT:
SUBMITTER: Dolma S
PROVIDER: S-EPMC5968455 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Cancer cell 20160601 6
Glioblastomas (GBM) grow in a rich neurochemical milieu, but the impact of neurochemicals on GBM growth is largely unexplored. We interrogated 680 neurochemical compounds in patient-derived GBM neural stem cells (GNS) to determine the effects on proliferation and survival. Compounds that modulate dopaminergic, serotonergic, and cholinergic signaling pathways selectively affected GNS growth. In particular, dopamine receptor D4 (DRD4) antagonists selectively inhibited GNS growth and promoted diffe ...[more]