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View From Outside the Viewing Sphere.

ABSTRACT: The 'viewing sphere', as defined by Euclid and explored by Gibson as the 'optic array', is generally thought of as wrapped around the eye. Can an observer step out of it? With currently popular photographic techniques, the spectator is forced to, because the viewing sphere is presented as a pictorial object. Then the question is whether human observers are able to use such pictorial representations in an intuitive manner. Can the spectator 'mentally step into the interior' of the pictorial viewing sphere? We explore this issue in a short experiment. Perhaps unsurprisingly, because the eye cannot see itself, the short answer is no.

SUBMITTER: Koenderink J

PROVIDER: S-EPMC5968667 | biostudies-literature | 2018 May-Jun

REPOSITORIES: biostudies-literature

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View From Outside the Viewing Sphere.

Koenderink Jan J van Doorn Andrea A Pepperell Robert R

i-Perception 20180523 3

The 'viewing sphere', as defined by Euclid and explored by Gibson as the 'optic array', is generally thought of as wrapped around the eye. Can an observer step out of it? With currently popular photographic techniques, the spectator is forced to, because the viewing sphere is presented as a pictorial object. Then the question is whether human observers are able to use such pictorial representations in an intuitive manner. Can the spectator 'mentally step into the interior' of the pictorial viewi ...[more]

PMID: 29854376

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Project description:Deep sequencing technology is revolutionizing our understanding of HIV/SIV evolution. It is known that acute SIV sequence variation within CD8 T lymphocyte (CD8-TL) epitopes is similar among MHC-identical animals, but we do not know whether this persists into the chronic phase. We now determine whether chronic viral variation in MHC-identical animals infected with clonal SIV is similar throughout the entire coding sequence when using a sensitive deep sequencing approach. We pyrosequenced the entire coding sequence of the SIV genome isolated from a unique cohort of four SIVmac239-infected, MHC-identical Mauritian cynomolgus macaques (MCM) 48 weeks after infection; one MCM in the cohort became an elite controller. Among the three non-controllers, we found that genome-wide sequences were similar between animals and we detected increased sequence complexity within 64% of CD8-TL epitopes when compared to Sanger sequencing methods. When we compared sequences between the MHC-matched controller and the three non-controllers, we found the viral population in the controller was less diverse and accumulated different variants than the viral populations in the non-controllers. Importantly, we found that initial PCR amplification of viral cDNA did not significantly affect the sequences detected, suggesting that data obtained by pyrosequencing PCR-amplified viral cDNA accurately represents the diversity of sequences replicating within an animal. This demonstrates that chronic sequence diversity across the entire SIV coding sequence is similar among MHC-identical animals with comparable viral loads when infected with the same clonal virus stock. Additionally, our approach to genome-wide SIV sequencing accurately reflects the diversity of sequences present in the replicating viral population. In sum, our study suggests that genome-wide pyrosequencing of immunodeficiency viruses captures a thorough and unbiased picture of sequence diversity, and may be a useful approach to employ when evaluating which sequences to include as part of a vaccine immunogen.

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View From Outside the Viewing Sphere.

Publications

View From Outside the Viewing Sphere.

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