Dataset Information

Serum Bicarbonate Concentration and Cognitive Function in Hypertensive Adults.

ABSTRACT: BACKGROUND AND OBJECTIVES:Cognitive function worsens as kidney function declines, but mechanisms contributing to this association are not completely understood. Metabolic acidosis, a common complication of CKD, leads to neural networks overexcitation and is involved in cerebral autoregulation. We aimed to evaluate the association between serum bicarbonate concentration as a measure of metabolic acidosis, and cognitive function in hypertensive adults with and without CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:Five cognitive summary scores were measured (global cognitive function, executive function, memory, attention/concentration, and language) in 2853 participants in the Systolic BP Intervention Trial (SPRINT). Multivariable linear regression models adjusted for demographics, comorbidities, systolic BP, medications, eGFR and albuminuria evaluated the cross-sectional association between bicarbonate and cognition at SPRINT baseline. In a subset (n=681) who underwent brain magnetic resonance imaging, the models were adjusted for white matter hyperintensity volume, vascular reactivity, and cerebral blood flow. RESULTS:The mean age (SD) was 68 (8.5) years. Global cognitive and executive functions were positively associated with serum bicarbonate (estimate [SEM]: 0.014 [0.006]; P=0.01, and 0.018 [0.006]; P=0.003, respectively). Each 1 mEq/L lower bicarbonate level had a similar association with global cognitive and executive function as being 4.3 and 5.4 months older, respectively. The association with global cognition persisted after magnetic resonance imaging findings adjustment (estimate [SEM]: 0.03 [0.01]; P=0.01). There was no association between serum bicarbonate level and memory, attention/concentration, and language. CONCLUSIONS:In a large cohort of hypertensive adults, higher serum bicarbonate levels were independently associated with better global cognitive and executive performance. (ClinicalTrials.gov: NCT01206062).

SUBMITTER: Dobre M

PROVIDER: S-EPMC5968905 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Serum Bicarbonate Concentration and Cognitive Function in Hypertensive Adults.

Dobre Mirela M Gaussoin Sarah A SA Bates Jeffrey T JT Chonchol Michel B MB Cohen Debbie L DL Hostetter Thomas H TH Raphael Kalani L KL Taylor Addison A AA Lerner Alan J AJ Wright Jackson T JT Rahman Mahboob M

Clinical journal of the American Society of Nephrology : CJASN 20180322 4

<h4>Background and objectives</h4>Cognitive function worsens as kidney function declines, but mechanisms contributing to this association are not completely understood. Metabolic acidosis, a common complication of CKD, leads to neural networks overexcitation and is involved in cerebral autoregulation. We aimed to evaluate the association between serum bicarbonate concentration as a measure of metabolic acidosis, and cognitive function in hypertensive adults with and without CKD.<h4>Design, setti ...[more]

PMID: 29567858

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Dataset Information

Serum Bicarbonate Concentration and Cognitive Function in Hypertensive Adults.

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Serum Bicarbonate Concentration and Cognitive Function in Hypertensive Adults.

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