Ontology highlight
ABSTRACT:
SUBMITTER: Starokozhko V
PROVIDER: S-EPMC5969064 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Starokozhko Viktoriia V Hemmingsen Mette M Larsen Layla L Mohanty Soumyaranjan S Merema Marjolijn M Pimentel Rodrigo C RC Wolff Anders A Emnéus Jenny J Aspegren Anders A Groothuis Geny G Dufva Martin M
Journal of tissue engineering and regenerative medicine 20180406 5
Hepatic differentiation of human-induced pluripotent stem cells (hiPSCs) under flow conditions in a 3D scaffold is expected to be a major step forward for construction of bioartificial livers. The aims of this study were to induce hepatic differentiation of hiPSCs under perfusion conditions and to perform functional comparisons with fresh human precision-cut liver slices (hPCLS), an excellent benchmark for the human liver in vivo. The majority of the mRNA expression of CYP isoenzymes and transpo ...[more]