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Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy)carbamates.

ABSTRACT: Ligand-enabled aza-Heck cyclizations and cascades of N-(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non-biased 6-exo aza-Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.

SUBMITTER: Hazelden IR

PROVIDER: S-EPMC5969259 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy)carbamates.

Hazelden Ian R IR Carmona Rafaela C RC Langer Thomas T Pringle Paul G PG Bower John F JF

Angewandte Chemie (International ed. in English) 20180322 18

Ligand-enabled aza-Heck cyclizations and cascades of N-(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non-biased 6-exo aza-Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines. ...[more]

PMID: 29488677

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