Ontology highlight
ABSTRACT:
SUBMITTER: Dahlin JS
PROVIDER: S-EPMC5969381 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Dahlin Joakim S JS Hamey Fiona K FK Pijuan-Sala Blanca B Shepherd Mairi M Lau Winnie W Y WWY Nestorowa Sonia S Weinreb Caleb C Wolock Samuel S Hannah Rebecca R Diamanti Evangelia E Kent David G DG Göttgens Berthold B Wilson Nicola K NK
Blood 20180327 21
Hematopoietic stem and progenitor cells (HSPCs) maintain the adult blood system, and their dysregulation causes a multitude of diseases. However, the differentiation journeys toward specific hematopoietic lineages remain ill defined, and system-wide disease interpretation remains challenging. Here, we have profiled 44 802 mouse bone marrow HSPCs using single-cell RNA sequencing to provide a comprehensive transcriptional landscape with entry points to 8 different blood lineages (lymphoid, megakar ...[more]