Ontology highlight
ABSTRACT:
SUBMITTER: Miyake K
PROVIDER: S-EPMC5969563 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Miyake Kentaro K Kawaguchi Kei K Kiyuna Tasuku T Miyake Masuyo M Igarashi Kentaro K Zhang Zhiying Z Murakami Takashi T Li Yunfeng Y Nelson Scott D SD Elliott Irmina I Russell Tara T Singh Arun A Hiroshima Yukihiko Y Momiyama Masashi M Matsuyama Ryusei R Chishima Takashi T Endo Itaru I Eilber Fritz C FC Hoffman Robert M RM
Cell cycle (Georgetown, Tex.) 20180101 6
Gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit is a rare type of sarcoma. The aim of this study was to determine drug sensitivity for a regionally-recurrent case of GIST using a patient-derived orthotopic xenograft (PDOX) model. The PDOX model was established in the anterior wall of the stomach. GIST PDOX models were randomized into 5 groups of 6 mice each when the tumor volume reached 60 mm<sup>3</sup>: G1, control group; G2, imatinib group (oral administratio ...[more]