Ontology highlight
ABSTRACT:
SUBMITTER: Perez OA
PROVIDER: S-EPMC5969998 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Perez Oriana A OA Yeung Stephen T ST Vera-Licona Paola P Romagnoli Pablo A PA Samji Tasleem T Ural Basak B BB Maher Leigh L Tanaka Masato M Khanna Kamal M KM
Science immunology 20171001 16
The spleen is an important site for generating protective immune responses against pathogens. After infection, immune cells undergo rapid reorganization to initiate and maintain localized inflammatory responses; however, the mechanisms governing this spatial and temporal cellular reorganization remain unclear. We show that the strategic position of splenic marginal zone CD169<sup>+</sup> macrophages is vital for rapid initiation of antibacterial responses. In addition to controlling initial bact ...[more]