HIAPP forms toxic oligomers in plasma.
Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez Camargo DC
PROVIDER: S-EPMC5970100 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
hIAPP forms toxic oligomers in plasma.
Rodriguez Camargo Diana C DC Garg Divita D Buday Katalin K Franko Andras A Rodriguez Camargo Andres A Schmidt Fabian F Cox Sarah J SJ Suladze Saba S Haslbeck Martin M Mideksa Yonatan G YG Gemmecker Gerd G Aichler Michaela M Mettenleiter Gabriele G Schulz Michael M Walch Axel Karl AK Hrabě de Angelis Martin M Feige Matthias J MJ Sierra Cesar A CA Conrad Marcus M Tripsianes Konstantinos K Ramamoorthy Ayyalusamy A Reif Bernd B
Chemical communications (Cambridge, England) 20180501 43
In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases. ...[more]
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