Ontology highlight
ABSTRACT:
SUBMITTER: Misra A
PROVIDER: S-EPMC5970166 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Misra Ashish A Feng Zhonghui Z Chandran Rachana R RR Kabir Inamul I Rotllan Noemi N Aryal Binod B Sheikh Abdul Q AQ Ding Ling L Qin Lingfeng L Fernández-Hernando Carlos C Tellides George G Greif Daniel M DM
Nature communications 20180525 1
Smooth muscle cells (SMCs) play a key role in atherogenesis. However, mechanisms regulating expansion and fate of pre-existing SMCs in atherosclerotic plaques remain poorly defined. Here we show that multiple SMC progenitors mix to form the aorta during development. In contrast, during atherogenesis, a single SMC gives rise to the smooth muscle-derived cells that initially coat the cap of atherosclerotic plaques. Subsequently, highly proliferative cap cells invade the plaque core, comprising the ...[more]